Preventing joint pain is another important aspect of managing Low T. If you know you have Low T or are at risk of developing it, taking steps to protect your joints can make a big difference. In addition to TRT, there are other treatments and lifestyle changes that can help manage joint pain. First, it's essential to recognize the symptoms of Low T and how they might relate to joint pain. Also, our study has a moderately large sample size, with 272 men and women age ≥60 years. Notably, however, symptoms are considered the patient‐relevant feature of OA rather than the extent of radiographic changes (45). On the other hand, we may have missed such an association due to the sample selection, where the most severely affected knee had undergone surgery and could not be assessed radiographically with respect to K/L grade. On the one hand, this finding is in line with prior studies where symptoms and the extent of radiographic changes show discrepant findings (36, 44). Further, an influence of testosterone on nociceptive processing (19, 20) and inflammatory response has been suggested in several studies (7, 9, 10, 11), all of which concern important pathways in the development of OA (42, 43). With regard to subgroups by BMI, there were inconsistent signals for men in the nonoperated knee. Differences between men and women were assessed by using Student’s t‐test for continuous variables and a chi‐square test for categorical variables. How to spot the signs of this common side effect and get your hormones back in sync. While not as common as low testosterone, high testosterone can be just as problematic. Research-backed tools, tactics, and techniques to maximize your health, delivered to your inbox every Monday. Kelly Bryant is a freelance writer and editor of over 20 years, covering the health and wellness space for media outlets like The Healthy, Reader's Digest, Parents and more It’s important to understand that joint pain can be caused by many different factors, not just Low T. Conditions like arthritis, gout, or injuries can also cause similar symptoms. Other factors, such as age, weight, and physical activity levels, also play a role in joint health. We will also look at how lifestyle changes can help manage joint pain and what preventive measures you can take to protect your joints if you have Low T. Throughout this article, we will answer some of the most common questions people have about Low T and joint pain. On the other hand, if your joint pain is caused by another condition, it’s still important to get the right diagnosis and treatment to prevent further complications. These factors can all contribute to joint pain and discomfort over time. It also has anti-inflammatory properties that can reduce the risk of joint inflammation and pain. Testosterone helps maintain the strength and integrity of bones and muscles, which support joints. In both genders, it plays a crucial role in regulating libido, mood, and even joint health. Always consult with a medical professional to determine the most appropriate treatment for your specific health needs.